Selections from current literature: benzodiazepines revisited.
نویسنده
چکیده
Having practised during the era when barbiturates were used as anxiolytics and hypnotics, I have a great appreciation for benzodiazepines. Unlike barbiturates, sudden withdrawal was never fatal, and suicide was virtually impossible if benzodiazepines were used alone. The first drug of this class, chlordiazepoxide (Librium) was approved in the USA in 1961, followed by diazepam (Valium) in 1969, which stayed at the top of the bestselling prescription drug list for a decade. Originally touted as having neither addiction potential nor causing a withdrawal syndrome, anecdotal reports in the late 1970s followed by more reliable reports in the 1980s established some evidence of abuse potential and discontinuation symptoms. Although these problems were relatively mild, sensationalistic lay press reports1 fuelled a perception that benzodiazepines were overused, dangerous drugs, and some states, such as New York, made them controlled substances, subject to similar prescribing restrictions as narcotics and barbiturates.
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عنوان ژورنال:
- Family practice
دوره 20 3 شماره
صفحات -
تاریخ انتشار 2003